This study will compare the
This new knowledge will enable development of new ways to improve the function of aged skin. The objectives of the study are to determine if topicallyapplied 17beta estradiol E2, alone or in combination with clobetasol, will produce histological and molecular effects distinguishable from vehicle in human skin. Endpoints will include protein and mRNA levels of collagen, elastin, and hyaluronic acid production and degradation in human skin, by steroid hormone receptors that are activated by estrogen or clobetasol. Skin biopsies of treated areas will be obtained at baseline and at subsequent timepoints.
This new knowledge will enable development of new ways to improve the function of aged skin. The objectives of the study are to determine if topicallyapplied 17beta estradiol E2, alone or in combination with clobetasol, will produce histological and molecular effects distinguishable from vehicle in human skin. Specifically, the study will focus on regulation of collagen, elastin, hyaluronic acid, and other components of skin connective tissue. Skin biopsies of treated areas will be obtained at baseline and at subsequent timepoints. Accumulating evidence suggests that estrogen, taken by post menopausal women, cause skin to look younger as consequence of reduced wrinkles.
The results from our studies will provide new knowledge regarding the molecular basis of skin aging. In addition, we will perform cDNA microanalysis to determine estrogenclobetasol target genes in human skin. Subjects will receive between one to twelve vehicle matching solution without any active ingredients, estrogen, andor clobetasol topical applications. Recent data indicate that shortterm topical estrogen 17beta estradiol treatment increases collagen production in damaged skin.
This new knowledge will enable development of new ways to improve the function of aged skin. The objectives of the study are to determine if topicallyapplied 17beta estradiol E2, alone or in combination with clobetasol, will produce histological and molecular effects distinguishable from vehicle in human skin. Subjects will receive between one to twelve vehicle matching solution without any active ingredients, estrogen, andor clobetasol topical applications. The sites to be treated will be buttock, hip, forearm, or facial skin.
The sites to be treated will be buttock, hip, forearm, or facial skin. This study will compare the molecular and microscopic effects from topical 17beta estradiol E2 when applied to the skin for shortterm duration. Specifically, the study will focus on regulation of collagen, elastin, hyaluronic acid, and other components of skin connective tissue. The results from our studies will provide new knowledge regarding the molecular basis of skin aging. This new knowledge will enable development of new ways to improve the function of aged skin.
Tags: treatment