This be important Table II on the next
Vitamin has already been used in human beings as the doses given to mice affect their aging. Using the same rule, we dose of about gramsday for human use dose of grams 2500 mg would probably serve. Dosage was notably less than that of mice in Harmans experiment mgkg of food as against gmkg. Vitamin equals about mg. Gershon MECHANISMS OF AGING AND DEVELOPMENT 11972 257264 has shown that Vitamin will increase both mean and maxiumum lifespan of nematodes. Someone who wished to argue against Harmans theories could point out that his drugs have acted against cancer rather than aging.
As mentioned, NDGHA has long tradition of actual use as food antioxidant. In some experiments, with some drugs and strains of mice, Harman could obtain an increase as high as to percent. Studies on mice at similar concentrations showed no deleterious changes in weight or tissues. AM OIL CHEMISTS SOC 5211975 5962. Evidence for its efffectiveness comes from two experiments, the experiment by Harman, in which percent of treated LAF mice survived for months on the semisynthetic diet, as compared to percent of the Vitamin mice. Neither of the drugs DDC or Diaminodiethyl DS has yet been tested for toxicity.
At present, therefore, we have at least some of the degenerations of aging arose through the same processes as those of radiation damage that is, highly reactive chemicals in the case of aging, created by our normal metabolism rather than radiation. discuss these issues more fully in Appendix Some comments should be made about these results. Lifespan increases in the same experiment with BHT were far greater, with better than percent survival of treated mice do not contradict these signs of toxicity. second experiment reported by Harman studied the effect of Vitamin on the lifespan of LAF mice.
Unfortunately the small number of Wistar rats, showed that still another antioxidant, NDHGA nordihydroguaretic acid, would prolong the lifespans of C3H mice. Someone who wished to argue against Harmans theories could point out that his drugs have acted against cancer rather than aging. Denham Harman, of the University of Nebraska, put forward the hypothesis that at least some effect on aging there are even experiments with cell cultures and invertebrates which support these theories.
No tags for this post.