Free radicals have also been found
Comparison of Lifespan, Functional Loss and DNA Loss Humans vs. The Human Aging Process Gene Loss as the Primary Cause of Aging As stated by the scientists in this article pg. 298, …. SOURCES OF FAILURE Our gradual move toward aging has been identified as occurring due to four major categories 1 GENE REPRESSION The first of these is gene repression the switching off of genes whose products are needed to maintain function.
years, ratio which implies that this loss limits the maximum lifespan of both species..
Comparison of Lifespan, Functional Loss and DNA Loss Humans vs. years, ratio which implies that this loss limits the maximum lifespan of both species..
4 DEPLETIONAL DEFECTS The final type of change that is responsible for the aging process is the physical loss of functioning parts. Dogs Tissue Species DNA Loss Lymphocytes Man 0. 45 per year Brain Dog 2. 10 per year Muscle Dog 3. 20 per year Heart Muscle Dog 3. 30 per year Average DNA Loss Dog 2. 87 per year Studies of humans after age 30, show the rate of loss per year is 57 times more rapid from dogs tissues than it is from the same human tissues.
genetic damage particularly gene loss is almost certainly or probably the central cause of aging. The first studies on human DNA dosage in regards to age indicated very substantial loss of DNA 0. 7 was then demonstrated in two separate regions of the human brain hippocampus and sensorimotor cortes. Moreover, the rate of loss per year is 57 times more rapid from dogs tissues than it is from the same human tissues. This number is very similar to the ratio of the maximum longevities of these two species 120 years vs.
4 DEPLETIONAL DEFECTS The final type of change that is responsible for the aging process is the physical loss of functioning parts. 2 INTRACELLULAR COMMUNICATION AND SPATIAL REARRANGEMENTS The second source of decreased function derives from the spatial relationships between working parts of individual cells, including their genetic information stores. There is small amount of evidence that suggests that longlived species are better able than short lived ones to counteract the effects of damaging substances or agents free radicals or UV irradiation as reflected in unscheduled DNA repair Hart and Setlow, 1976.
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